Discussion

All Global Nutrition Formulas Meet or Exceed cGMP Quality Standards

•• Designed to Support a Healthy Energy Level*

•• Supports Electrolyte Replacement*

•• Helps Fight Free Radicals with Antioxidant Nutrients, Including

S-Acetyl-L-Glutathione and 500 mg of Vitamin C*

•• Provides an Alternative to Ordinary Caffeine*

•• Provides Ingredients That Support ATP Biosynthesis*

Clinical Applications

PURENERGY™

Purenergy is an innovative patent-protected ingredient that combines caffeine with pTeroPure® pterostilbene—a highly bioavailable analog

of resveratrol—to form a unique co-crystal structure. It appears that this unique structure affects the way the body utilizes caffeine. As such,

it may offer significant advantages over caffeine alone.*

Study Findings

In a rat study (n=6), the half-life of the caffeine from Purenergy was eight hours, while that of ordinary caffeine was just three hours.[1] In a

preliminary, four-week, single-blind, crossover human study (n=12) that compared 232 mg of Purenergy (providing 99.76 mg of caffeine) to

100 mg of ordinary caffeine, the following effects were demonstrated[2,3]:

• Purenergy delivered almost 30% more caffeine into the blood than ordinary caffeine.*

• The absorption rate of the caffeine from Purenergy was significantly slower by approximately 30% compared to ordinary caffeine.*

• The half-life of the caffeine from Purenergy was extended significantly by approximately 25% compared to ordinary caffeine.*

• At 4 hours, serum showed 45% more caffeine from Purenergy compared to ordinary caffeine.*

• At 6 hours, serum showed 51% more caffeine from Purenergy compared to ordinary caffeine.*

• Purenergy had no adverse effect.*

While the results of these studies are promising, larger studies are needed to validate the findings and determine if these findings translate

into a lengthened energy effect.*

More Energy

Taken together, data from these studies suggest that the effects of caffeine from Purenergy may last longer than the effects from ordinary

caffeine and point to a potential for reducing total caffeine intake due to Purenergy’s more efficient delivery and slower absorption rate.

These are encouraging factors for people who wish to reduce their caffeine intake.*

Slower Caffeine “Finish”

Scientists are researching whether or not the extended half-life and slower absorption rate of caffeine from Purenergy can produce a more

moderated and gradual finish. This may help prevent the “crash” associated with regular caffeinated energy products and may give Vitality

Alive & Kicking an advantage over formulas that use ordinary caffeine.*

All-Natural, No Sugars

Vitality Alive & Kicking relies on natural ingredients, not ephedra or artificial stimulants. Furthermore, it provides only five grams of

carbohydrates and zero sugars. By using natural flavors and stevia in place of sugar and other carbohydrates, the typical “sugar high” that

is associated with many energy drinks can be avoided. Equally important, Vitality Alive & Kicking contains no artificial colors.*

Caffeine, in General

In animal and human studies, caffeine has demonstrated positive effects on athletic performance, fatigue, and cognitive functions, such as

supporting a healthy memory.[4-8] According to Meeusen et al, research on caffeine suggests its performance-enhancing effect is related to

antagonism of the adenosine receptors that influence the dopaminergic and other neurotransmitter systems.*[9]

Pterostilbene

In the aforementioned human study, Purenergy also delivered approximately 50% more total pterostilbene into the blood than pTeroPure

delivered alone,[2] thus potentially enhancing the functional benefits of pterostilbene. Pterostilbene is a highly bioavailable analog of

resveratrol—a stilbenoid found in blueberries and grapes. Compared to resveratrol, pterostilbene is four times more bioavailable,[10] has

a seven times greater half-life,[11] exhibits greater oral absorption and metabolic stability (pterostilbene is more lipophilic), and produces

two to four times greater cellular uptake.[12] Aside from resveratrol’s well-known antioxidant benefits that support cardiovascular health,

pterostilbene is also known to activate certain proteins (i.e., SIRT1 and PGC-1α) involved in increasing mitochondrial biogenesis and